Society for Actinomycetes Japan The
Society for
Actinomycetes
Japan



Established in 1955 and recognized in 1985 by the Science Council of Japan.
[Japanese Page]
[ISBA18] 18th International Symposium on the Biology of Actinomycetes
Jeju island, Korea during 23-27 May 2017
Abstract Oral, Feb. 22nd, 2017; Poster, Apr. 15th, 2017.
2016 Annual Meeting of SAJ (Sep. 8-9, Tokyo)

Outline of SAJ

Newsletter
(Actinomycetologica)

Official Journal

JA Free Access (members only)

Digital Atlas of Actinomycetes Ver. 2

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Topics
[2017/01/17] Newsletter Actinomycetologica 30(2) is out.
[2016/07/06] Newsletter Actinomycetologica 30(1) is out.
[2016/06/17] The ISBA18 webpage is now live on the internet.
[2016/05/25] [GIM2016] Abstract submission: 1 June 2016
[2015/12/25] Official newsletter Actinomycetologica Vol.29 No.2 is out.
[2015/10/7] Professor Satoshi Omura, an honorary member of the SAJ, was awarded the 2015 Nobel Prize in Physiology or Medicine.
Natural Product Discovery & Development in The Post Genomic Era (San Diego, Jan. 11-14, 2015)
ISBA'17 (Kusadasi, Turkey, Oct. 8-12, 2014)
ESF-EMBO symposium on the Synthetic Biology of Antibiotic Production II (Spain, 8/30-9/4 2014)
JA's AOP web feed

Verification of oligomycin A structure: synthesis and biological evaluation of 33-dehydrooligomycin A April 19 2017. doi:10.1038/ja.2017.48 Lyudmila N Lysenkova, Oleg Y Saveljev, Natalya E Grammatikova, Vladimir B Tsvetkov, Olga B Bekker, Valery N Danilenko, Lyubov G Dezhenkova, Eugene E Bykov, Olga A Omelchuk, Alexander M Korolev & Andrey E Shchekotikhin

Aurachin SS, a new antibiotic from Streptomyces sp. NA04227 April 19 2017. doi:10.1038/ja.2017.50 Mei Zhang, Cheng Long Yang, Yong Sheng Xiao, Bo Zhang, Xin Zhao Deng, L i Yang, Jing Shi, Y i Shuang Wang, Wei Li, Rui Hua Jiao, Ren Xiang Tan & Hui Ming Ge

Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli April 12 2017. doi:10.1038/ja.2017.38 Gergana A Vandova, Robert V O'Brien, Brian Lowry, Thomas F Robbins, Curt R Fischer, Ronald W Davis, Chaitan Khosla, Colin JB Harvey & Maureen E Hillenmeyer

In vitro antibacterial activity of MGDG-palmitoyl from Oscillatoria acuminata NTAPC05 against extended-spectrum β-lactamase producers April 5 2017. doi:10.1038/ja.2017.40 Abdul Azees Parveez Ahamed, Mohammed Uddin Rasheed, Kalilurrahuman Peer Muhamed Noorani, Nazar Reehana, Subramanian Santhoshkumar, Yousuff Mohamed Mohamed Imran, Naiyf S Alharbi, Chinnathambi Arunachalam, Sulaiman Ali Alharbi, Mohammad Abdulkader Akbarsha & Nooruddin Thajuddin

Biochemical characterization of CTX-M-166, a new CTX-M β-lactamase produced by a commensal Escherichia coli isolate April 5 2017. doi:10.1038/ja.2017.42 Vera Manageiro, Rafael Graça, Eugénia Ferreira, Lurdes Clemente, Richard Bonnet & Manuela Caniça

Formal synthesis of Thienamycin April 5 2017. doi:10.1038/ja.2017.44 Michał Pieczykolan, Bartłomiej Furman & Marek Chmielewski

Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candidaalbicans biofilm formation and hyphal growth April 5 2017. doi:10.1038/ja.2017.45 Jie Wang, Qi-Feng Yao, Muhammad Amin, Xu-Hua Nong, Xiao-Yong Zhang & Shu-Hua Qi

New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066 April 5 2017. doi:10.1038/ja.2017.46 Mingwei Sun, Xiaotong Chen, Wenjun Li, Chunhua Lu & Yuemao Shen

Bioactive secondary metabolites produced by an endophytic fungus Gaeumannomyces sp. JS0464 from a maritime halophyte Phragmites communis March 29 2017. doi:10.1038/ja.2017.39 Changyeol Lee, Soonok Kim, Wei Li, Sunghee Bang, Hanna Lee, Hyun-Jung Lee, Eun-Young Noh, Jung-Eun Park, Woo Young Bang & Sang Hee Shim

Conjugative ESBL plasmids differ in their potential to rescue susceptible bacteria via horizontal gene transfer in lethal antibiotic concentrations March 29 2017. doi:10.1038/ja.2017.41 Sari Mattila, Pilvi Ruotsalainen, Ville Ojala, Timo Tuononen, Teppo Hiltunen & Matti Jalasvuori

γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination March 22 2017. doi:10.1038/ja.2017.35 Tatsuya Shirahata, Chieko Ino, Fumi Mizuno, Yoshihisa Asada, Masao Hirotani, George A Petersson, Satoshi Ōmura, Takafumi Yoshikawa & Yoshinori Kobayashi

The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis March 15 2017. doi:10.1038/ja.2017.19 Juan F Martín, Antonio Rodríguez-García & Paloma Liras

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities March 15 2017. doi:10.1038/ja.2017.28 Atsushi Fukumoto, Yong-Pil Kim, Atsuko Matsumoto, Yoko Takahashi, Makoto Suzuki, Hideyuki Onodera, Hiroshi Tomoda, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Satoshi Ōmura & Kazuro Shiomi

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation March 15 2017. doi:10.1038/ja.2017.29 Atsushi Fukumoto, Yong-Pil Kim, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka, Hideaki Hanaki, Satoshi Ōmura & Kazuro Shiomi

Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis March 15 2017. doi:10.1038/ja.2017.31 Naftale Katz, Neusa Araújo, Paulo Marcos Zech Coelho, Carlos Medicis Morel, Ana Rosa Linde-Arias, Takeshi Yamada, Yuki Horimatsu, Koh Suzuki, Toshiaki Sunazuka & Satoshi Ōmura

Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms March 15 2017. doi:10.1038/ja.2017.33 Ayako Nara, Takuya Hashimoto, Mamoru Komatsu, Makoto Nishiyama, Tomohisa Kuzuyama & Haruo Ikeda

Structure and antibacterial activities of new cyclic peptide antibiotics, pargamicins B, C and D, from Amycolatopsis sp. ML1-hF4 March 15 2017. doi:10.1038/ja.2017.34 Hideki Hashizume, Ryuichi Sawa, Kazuma Yamashita, Yoshio Nishimura & Masayuki Igarashi

Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16 March 15 2017. doi:10.1038/ja.2017.37 Jia-hui Xu, Kang-bo Gu, Dao-Jing Zhang, Yuan-Guang Li & Li Tian

Endophytic actinomycetes: promising source of novel bioactive compounds March 8 2017. doi:10.1038/ja.2017.20 Atsuko Matsumoto & Yōko Takahashi

OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum March 8 2017. doi:10.1038/ja.2017.21 Catalina F Pérez Hemphill, Parichat Sureechatchaiyan, Matthias U Kassack, Raha S Orfali, Wenhan Lin, Georgios Daletos & Peter Proksch

Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes March 8 2017. doi:10.1038/ja.2017.27 Sandip S Shinde, Atsushi Minami, Zhi Chen, Tetsuo Tokiwano, Tomonobu Toyomasu, Nobuo Kato, Takeshi Sassa & Hideaki Oikawa

Two new sacrolide-class oxylipins from the edible cyanobacterium Aphanothece sacrum March 8 2017. doi:10.1038/ja.2017.32 Naoya Oku, Sayaka Hana, Miyako Matsumoto, Kohsuke Yonejima, Keijiroh Tansei, Yasuhiro Isogai & Yasuhiro Igarashi

Trienylfuranol A and trienylfuranone A–B: metabolites isolated from an endophytic fungus, Hypoxylon submoniticulosum, in the raspberry Rubus idaeus March 1 2017. doi:10.1038/ja.2017.18 Kevin M N Burgess, Ashraf Ibrahim, Dan Sørensen & Mark W Sumarah

Identification of tirandamycins as specific inhibitors of the futalosine pathway March 1 2017. doi:10.1038/ja.2017.22 Yasushi Ogasawara, Kensuke Kondo, Ayumi Ikeda, Rikako Harada & Tohru Dairi

Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate March 1 2017. doi:10.1038/ja.2017.24 Wayne KW Chou, Colin A Gould & David E Cane

Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7 March 1 2017. doi:10.1038/ja.2017.26 Yasuhiro Takehana, Maya Umekita, Masaki Hatano, Chiaki Kato, Ryuichi Sawa & Masayuki Igarashi

The antibiotic resistance crisis, with a focus on the United States March 1 2017. doi:10.1038/ja.2017.30 Evan Martens & Arnold L Demain

Molecular epigenetic approach activates silent gene cluster producing dimeric bis-spiro-azaphilones in Chaetomium globosum CBS148.51 March 1 2017. doi:10.1038/ja.2017.4 Meng-Hua Wang, Tao Jiang, Gang Ding, Shu-Bin Niu, Xue-Wei Wang, Meng Yu, Yu-Cheng Gu, Qiu-Bo Zhang, Jia-Huan Chen, Hong-Mei Jia & Zhong-Mei Zou

Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor February 22 2017. doi:10.1038/ja.2017.16 Masaki Ohtawa, Shiho Arima, Risa Shimizu, Naomi Hanatani, Eri Shimizu, Kazuro Shiomi, Kiyoshi Kita, Satoshi Ōmura & Tohru Nagamitsu

Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32 February 22 2017. doi:10.1038/ja.2017.17 Xiangcheng Zhu, Yanwen Duan, Zhaomeng Cui, Zhen Wang, Zengxia Li, Yun Zhang, Jianhua Ju & Hongbo Huang

The efficacy of different anti-microbial metals at preventing the formation of, and eradicating bacterial biofilms of pathogenic indicator strains February 15 2017. doi:10.1038/ja.2017.10 Natalie Gugala, Joe A Lemire & Raymond J Turner

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations February 15 2017. doi:10.1038/ja.2017.11 Andy Crump

Biosynthetic studies on terpenoids produced by Streptomyces February 15 2017. doi:10.1038/ja.2017.12 Tomohisa Kuzuyama

Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D February 15 2017. doi:10.1038/ja.2017.13 Dong Yang, Mostafa E Rateb, Nan Wang & Ben Shen

Acremopeptin, a new peptaibol from Acremonium sp. PF1450 February 15 2017. doi:10.1038/ja.2017.15 Masatomi Iijima, Masahide Amemiya, Ryuichi Sawa, Yumiko Kubota, Takao Kunisada, Isao Momose, Manabu Kawada & Masakatsu Shibasaki

Two new polyketides from the ascomycete fungus Leptosphaeria sp. February 15 2017. doi:10.1038/ja.2017.5 Jie Lin, Renlei Wang, Guohua Xu, Zhengfeng Ding, Xueshen Zhu, Erwei Li & Ling Liu

Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus February 15 2017. doi:10.1038/ja.2017.7 Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya & Kazuhisa Sekimizu

Genus Kitasatospora, taxonomic features and diversity of secondary metabolites February 15 2017. doi:10.1038/ja.2017.8 Yōko Takahashi

Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2 February 15 2017. doi:10.1038/ja.2017.9 Isao Momose & Takumi Watanabe

Streptomyces euryhalinus sp. nov., a new actinomycete isolated from a mangrove forest February 8 2017. doi:10.1038/ja.2017.3 Kaushik Biswas, Jayanta D Choudhury, Riddhi Mahansaria, Malay Saha & Joydeep Mukherjee

Antarlides F–H, new members of the antarlide family produced by Streptomyces sp. BB47 February 8 2017. doi:10.1038/ja.2017.6 Shun Saito, Takahiro Fujimaki, Watanalai Panbangred, Ryuichi Sawa, Yasuhiro Igarashi & Masaya Imoto

Lipophilic teicoplanin pseudoaglycon derivatives are active against vancomycin- and teicoplanin-resistant enterococci February 1 2017. doi:10.1038/ja.2017.2 Zsolt Szűcs, Ilona Bereczki, Magdolna Csávás, Erzsébet Rőth, Anikó Borbás, Gyula Batta, Eszter Ostorházi, Réka Szatmári & Pál Herczegh

Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample January 25 2017. doi:10.1038/ja.2016.169 Bin Yang, Huaming Tao, Xiao-Chu Qin, Zhen Wang, Junde Dong, Xiuping Lin, Xuefeng Zhou, Jian-Lin Li, Zheng-Chao Tu & Yonghong Liu

Molecular beacons to identify gifted microbes for genome mining January 25 2017. doi:10.1038/ja.2017.1 Richard H Baltz

The ups and downs of drug discovery: the early history of Fidaxomicin January 18 2017. doi:10.1038/ja.2016.157 James B McAlpine

Simamycin (5′-O-geranyluridine): a new prenylated nucleoside from Streptomyces sp. January 18 2017. doi:10.1038/ja.2016.163 Yasuhiro Igarashi, Takayuki Kyoso, Youngju Kim & Tsutomu Oikawa

Thiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis January 18 2017. doi:10.1038/ja.2016.165 Sheo B Singh, Libo Xu, Peter T Meinke, Natalia Kurepina, Barry N Kreiswirth, David B Olsen & Katherine Young

The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues January 18 2017. doi:10.1038/ja.2016.166 Takamichi Imaizumi, Hiroshi Nakagawa, Ran Hori, Yasuo Watanabe, Shiro Soga, Kyoichiro Iida & Hideyuki Onodera

Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684 January 18 2017. doi:10.1038/ja.2016.167 Toshihiko Nogawa, Noriko Ogita, Yushi Futamura, Shigenori Negishi, Nobumoto Watanabe & Hiroyuki Osada

MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane January 18 2017. doi:10.1038/ja.2016.168 Yusuke Kanda, Youhei Yamasaki, Satomi Shimura, Shinji Kamisuki, Fumio Sugawara, Yoko Nagumo & Takeo Usui

Enhanced dereplication of fungal cultures via use of mass defect filtering January 11 2017. doi:10.1038/ja.2016.145 Noemi D Paguigan, Tamam El-Elimat, Diana Kao, Huzefa A Raja, Cedric J Pearce & Nicholas H Oberlies

Elmenols C-H, new angucycline derivatives isolated from a culture of Streptomyces sp. IFM 11490 January 11 2017. doi:10.1038/ja.2016.158 Yixizhuoma, Naoki Ishikawa, Mohamed S Abdelfattah & Masami Ishibashi

Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alisma orientale January 11 2017. doi:10.1038/ja.2016.160 Mei Liu, Pei Huang, Qian Wang, Biao Ren, Ayokunmi Oyeleye, Miaomiao Liu, Jingyu Zhang, Xiaolin Li, Xiaoping Zhang, Lixin Zhang & Xueting Liu

Kribellosides, novel RNA 5′-triphosphatase inhibitors from the rare actinomycete Kribbella sp. MI481-42F6 January 11 2017. doi:10.1038/ja.2016.161 Masayuki Igarashi, Ryuichi Sawa, Manabu Yamasaki, Chigusa Hayashi, Maya Umekita, Masaki Hatano, Toshinobu Fujiwara, Kiyohisa Mizumoto & Akio Nomoto

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1 December 21 2016. doi:10.1038/ja.2016.152 Takashi Fukuda, Misaki Takahashi, Kenichiro Nagai, Enjuro Harunari, Chiaki Imada & Hiroshi Tomoda

Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506 December 21 2016. doi:10.1038/ja.2016.153 Shan Lu, Shinichi Nishimura, Masashi Ito, Taira Kato & Hideaki Kakeya

Synthesis and antibacterial activity of novel lincomycin derivatives. II. Exploring (7S)-7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives December 7 2016. doi:10.1038/ja.2016.139 Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Eijiro Umemura, Takashi Watanabe, Megumi Kumura, Takuji Yoshida & Keiichi Ajito

Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance December 7 2016. doi:10.1038/ja.2016.141 Tomoyasu Hirose, Yasuhiro Kojima, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Kazuro Shiomi, Satoshi Ōmura & Toshiaki Sunazuka

Nature nurtures the design of new semi-synthetic macrolide antibiotics November 30 2016. doi:10.1038/ja.2016.137 Prabhavathi Fernandes, Evan Martens & David Pereira

Related Links
FramePlot 2.3 - protein-coding region prediction tool
2ndFind - secondary metabolite biosynthetic gene discovery tool
Codon Usage Table of The Genus Streptomyces (GenBank R.118)
Genome:
Streptomyces griseus IFO 13350
Streptomyces avermitilis MA-4680
Streptomyces coelicolor A3(2)
Saccharopolyspora erythraea NRRL 2338
Mycobacterium tuberculosis H37Rv
Corynebacterium diphtheriae
Corynebacterium efficiens YS-314
Noardia farcinica IFM 10152
Rhodococcus erythropolis PR4
Rhodococcus opacus B4
Rhodococcus jostii RHA1
Frankia spp.
National BioResource Project (NBRP)
Journal of Antibiotics
Novel Antibiotics DataBase [Download] [Search]
NCBI Taxonomy